What is GCL1815 and how was it selected from 10,000 strains?

What is GCL1815 and how was it selected from 10,000 strains?

In the article “Lactic Acid Bacteria That Support the Immune System: The GCL1815,” we introduced the basic mechanisms of the immune system and explained how the GCL1815 supports the immune system.
On this page, we take a closer look at how the GCL1815 was selected and the unique characteristics that make it stand out.

GCL1815: A carefully selected strain

GCL1815 was selected based on three key indicators related to the immune system.

The GCL1815 is a lactic acid bacterium selected for its ability to “protect, coordinate, and fight.”

Scientific Evidence from Human Studies

In a human study, continuous intake of GCL1815 was associated with a reduction in self-reported cold-like symptoms. A decrease in the tendency for symptoms such as fatigue, tiredness, nasal congestion, and feverishness to occur, as well as a reduction in the severity of symptoms, was also observed.

Key features of GCL1815

A unique feature of GCL1815 is its ability to interact with two types of dendritic cells (pDCs and cDC1s), which play central roles in coordinating immune responses. Human studies have shown that GCL1815 enhances the activity of both pDCs and cDC1s.
By supporting these key immune cells, GCL1815 may help to both fortify the body’s protective barriers and strengthen its ability to fight back against threats, thereby promoting a well-balanced immune response.

Glossary

Antibody
A protein produced by the immune system that binds to specific viruses, bacteria, or other foreign substances. It helps neutralize threats and supports their removal by immune cells.

IgA (Immunoglobulin A)
A type of antibody that is abundant in mucosal tissues, saliva, and breast milk. It plays a central role in mucosal immunity by helping prevent foreign substances such as viruses and bacteria from entering the body.

Interleukin
A messenger molecule used by immune cells to communicate. It helps coordinate immune responses by controlling when and how different immune cells act.

IL-12 (Interleukin-12)
A type of interleukin that helps activate immune responses. In particular, it helps strengthen immune responses that directly target viruses and other foreign substances.

Dendritic cell
An immune cell that detects foreign substances and relays that information to other immune cells. It serves as a key coordinator of immune responses.

pDC (Plasmacytoid dendritic cell)
A type of dendritic cell that responds to viruses. During a viral infection, it releases large amounts of immune signals, helping to activate innate immunity and support the body's early defense against infection.

cDC1 (Type 1 conventional dendritic cell)
A type of dendritic cell that helps communicate information about viruses and other foreign substances to immune cells. It promotes adaptive immune responses and supports effective protection against infection.

cDC2 (Type 2 conventional dendritic cell)
A type of dendritic cell involved in regulating immune responses against bacteria and other foreign substances. It is also closely involved in the immune response that produces antibodies.
Helper T cell
An immune cell that helps coordinate adaptive immune responses. It sends signals to other immune cells, guiding how they respond to foreign substances.

Killer T cell (Cytotoxic T cell)
A type of T cell that directly attacks and eliminates virus-infected cells and other abnormal cells. It helps prevent infections from spreading throughout the body.

B cell
An immune cell that is responsible for producing antibodies. B cells also play a role in immune memory, helping the body respond more quickly and effectively when the same foreign substance is encountered again.

NK Cell (Natural killer cell)
A type of immune cell that quickly detects and destroys infected or abnormal cells. NK cells are a key component of innate immunity and help provide early protection against infection.







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